The COSMOS Trial
The COSMOS Study, conducted by Harvard University and Brigham and Women’s Hospital with about 21,000 participants from 2015 to 2022, found that daily intake of 200mg cacao flavanols significantly lowered cardiovascular mortality and improved blood vessel function. Mindkore cacao provides over three times the daily amount of flavanols used in the study, guaranteeing the aforementioned clinical dosage, and then some.
UK Biobank Flavonoid Intake Study
The UK Biobank Flavonoid Intake Study, led by researchers at the University of Edinburgh and involving approximately 500,000 participants between 2006 and 2023, investigated the relationship between dietary flavonoid consumption and health outcomes. The study found that higher flavonoid intake (±430.5mg per day) was significantly associated with a lower risk of chronic diseases (like type 2 diabetes) and premature death, highlighting the broad protective effects of these plant compounds on human health. This large-scale, long-term study is one of the most comprehensive to date on flavonoids and mortality. While this study went with a substantial amount of flavanols, Mindkore high-performance cacao (at 5 gram per day) goes ~50% above that amount, guaranteeing the aforementioned clinical dosage.
Study findings (Nature.com)
Nurses' Health Study & Health Professionals Follow-up Study (Harvard)
The Nurses' Health Study and Health Professionals Follow-up Study, conducted by Harvard T.H. Chan School of Public Health with over 86,000 participants since the 1970s and 1980s, respectively, have focused on flavonoid intake since around 2010. These long-running studies reveal that higher flavonoid consumption is associated with reduced physical decline and improved cognitive and mental health, emphasizing flavonoids’ role in healthy aging. The study emphasizes the importance of incorporating flavonoid-rich foods into the diet as a simple strategy to support healthy aging.
Mastroiacovo et al.
Mastroiacovo et al. (2014) conducted an 8-week study involving 72 cognitively healthy older adults to investigate the effects of daily intake of 520 mg cocoa flavanols. The participants showed significant improvements in various cognitive functions after the intervention. Notably, these benefits were observed without any reported adverse effects, indicating the safety of the dosage. The study suggests that regular consumption of flavanol-rich cocoa may support cognitive health in aging populations. These findings add to growing evidence that cocoa flavanols can positively influence brain function. Overall, the research highlights the potential of cocoa as a simple dietary approach to maintain or enhance cognition in older adults.
